Mitochondrial dysfunction is a hallmark of idiopathic neurodegenerative diseases, including
Parkinson disease, amyotrophic lateral sclerosis, Alzheimer disease and Huntington …

Selective autophagy is a lysosomal degradation pathway that is critical for maintaining
cellular homeostasis by disposing of harmful cellular material. While the mechanisms by …

Damaged mitochondria are selectively eliminated in a process called mitophagy. PINK1 and
Parkin amplify ubiquitin signals on damaged mitochondria, which are then recognized by …

Abstract Thymidine kinase 1 (TK1), a crucial enzyme in DNA synthesis, is highly expressed
in various cancers. However, the mechanisms underlying its elevated expression and the …

Autophagy mediates the degradation of harmful material within lysosomes. In aggrephagy,
the pathway mediating the degradation of aggregated, ubiquitinated proteins, this cargo …

Chronic HCV infection is a risk factor for end-stage liver disease, leading to a major burden
on public health. Mitophagy is a specific form of selective autophagy that eliminates …

Cytopathology induced by methamphetamine (METH) is reminiscent of degenerative
disorders such as Parkinson's disease, and it is characterized by membrane organelles …