The pivotal role of lysosomes in cellular processes is increasingly appreciated. An
understanding of the balanced interplay between the activity of acidic hydrolases, lysosomal …

Introduction: Gaucher disease, the autosomal recessive deficiency of the lysosomal enzyme
glucocerebrosidase, is associated with wide phenotypic diversity including non …

Common forms of Parkinson's disease have long been described as idiopathic, with no
single penetrant genetic factor capable of influencing disease aetiology. Recent genetic …

Parkinson's disease is a neurodegenerative disorder primarily known for typical motor
features that arise due to the loss of dopaminergic neurons in the substantia nigra. However …

Over the past decades, tremendous progress has been made in the field of Gaucher
disease, the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Many of the …

An exciting development in the field of neurodegeneration is the association between the
rare monogenic disorder Gaucher disease and the common complex disorder Parkinson …

Dysfunction in the macrophage lysosomal system including reduced acidity and diminished
degradative capacity is a hallmark of atherosclerosis, leading to blunted clearance of excess …

Fluorogenic substrates are emerging tools that enable studying enzymatic processes within
their native cellular environments. However, fluorogenic substrates that function within live …

Glucocerebrosidase (GCase) is implicated in both a rare, monogenic disorder (Gaucher
disease, GD) and a common, multifactorial condition (Parkinson's disease, PD); hence, it is …

Gaucher disease is an autosomal recessive lysosomal storage disorder resulting from
mutations in the gene GBA1 that lead to a deficiency in the enzyme glucocerebrosidase …