[HTML][HTML] Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …
Phage therapy: a revolutionary shift in the management of bacterial infections, pioneering new horizons in clinical practice, and reimagining the arsenal against …
The recent approval of experimental phage therapies by the FDA and other regulatory
bodies with expanded access in cases in the United States and other nations caught the …
bodies with expanded access in cases in the United States and other nations caught the …
Phage therapy: past, present and future
As an ancient proverb states,“The enemy of my enemy is my friend.” The so-called strictly
lytic or virulent bacteriophages (phages)—especially the viruses of pathogenic bacteria …
lytic or virulent bacteriophages (phages)—especially the viruses of pathogenic bacteria …
In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
The emergence of multidrug resistant (MDR) pathogenic bacteria is jeopardizing the value
of antimicrobials, which had previously changed the course of medical science. In this study …
of antimicrobials, which had previously changed the course of medical science. In this study …
[HTML][HTML] Choline Binding Proteins from Streptococcus pneumoniae: A Dual Role as Enzybiotics and Targets for the Design of New Antimicrobials
Streptococcus pneumoniae (pneumococcus) is an important pathogen responsible for acute
invasive and non-invasive infections such as meningitis, sepsis and otitis media, being the …
invasive and non-invasive infections such as meningitis, sepsis and otitis media, being the …
Improving the lethal effect of Cpl-7, a pneumococcal phage lysozyme with broad bactericidal activity, by inverting the net charge of its cell wall-binding module
R Díez-Martínez, H de Paz, N Bustamante… - Antimicrobial agents …, 2013 - journals.asm.org
Phage endolysins are murein hydrolases that break the bacterial cell wall to provoke lysis
and release of phage progeny. Recently, these enzymes have also been recognized as …
and release of phage progeny. Recently, these enzymes have also been recognized as …
Characterization of five novel endolysins from Gram-negative infecting bacteriophages
M Walmagh, B Boczkowska, B Grymonprez… - Applied microbiology …, 2013 - Springer
We here characterize five globular endolysins, encoded by a set of Gram-negative infecting
bacteriophages: BcepC6gp22 (Burkholderia cepacia phage BcepC6B), P2gp09 …
bacteriophages: BcepC6gp22 (Burkholderia cepacia phage BcepC6B), P2gp09 …
[HTML][HTML] Bacteria in the respiratory tract—how to treat? Or do not treat?
C Prat, A Lacoma - International Journal of Infectious Diseases, 2016 - Elsevier
Background Acute and chronic respiratory tract infections are a common cause of
inappropriate antimicrobial prescription. Antimicrobial therapy leads to the development of …
inappropriate antimicrobial prescription. Antimicrobial therapy leads to the development of …
Enzybiotics: endolysins and bacteriocins
The growing prevalence within community and healthcare settings of antibiotic resistant
Gram-positive and Gram-negative bacterial pathogens is alarming. Particularly concerning …
Gram-positive and Gram-negative bacterial pathogens is alarming. Particularly concerning …
High frequency acoustic nebulization for pulmonary delivery of antibiotic alternatives against Staphylococcus aureus
The increasing prevalence of multidrug resistant bacteria has warranted the search for new
antimicrobial agents as existing antibiotics lose their potency. Among these, bacteriophage …
antimicrobial agents as existing antibiotics lose their potency. Among these, bacteriophage …