Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible
paths to platelet factor 4 autoimmunity | PLOS Medicine Skip to main content Advertisement …

Rationale: Coronavirus disease 2019 (COVID-19) is characterized by increased incidence
of microthrombosis with hyperactive platelets sporadically containing viral RNA. It is unclear …

Objectives Hyper-inflammation caused by COVID-19 may be mediated by mast cell
activation (MCA) which has also been hypothesized to cause Long-COVID (LC) symptoms …

(1) Background: Since its discovery, COVID-19 has caused more than 256 million cases,
with a cumulative death toll of more than 5.1 million, worldwide. Early identification of …

Given the evidence for a hyperactive platelet phenotype in COVID-19, we investigated
effector cell properties of COVID-19 platelets on endothelial cells (ECs). Integration of EC …

Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern
whether ACE2 receptor plays a role in this interaction. The current study showed that SARS …

Extracellular vesicles (EVs) being defined as lipid-bilayer encircled particles are released by
almost all known mammalian cell types and represent a heterogenous set of cell fragments …

COVID-19 has emerged as a devastating disease in the last 2 years. Many authors
appointed to the importance of kallikrein-kinin system (KKS) in COVID-19 pathophysiology …

Background The rapid emergence and global dissemination of the Omicron variant of SARS-
CoV-2 have posed formidable challenges in public health. This scenario underscores the …