Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
International union of basic and clinical pharmacology. XCVIII. Histamine receptors
P Panula, PL Chazot, M Cowart, R Gutzmer… - Pharmacological …, 2015 - Elsevier
Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases
The potential contributions of the brain histaminergic system in neurodegenerative diseases,
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …
Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential
C Geoffroy, P Paoletti, L Mony - The Journal of Physiology, 2022 - Wiley Online Library
NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …
Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer's disease
J Wang, B Liu, Y Xu, M Yang, C Wang, M Song… - Aging …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is an age‐related neurodegenerative disease, and the imbalance
between production and clearance of β‐amyloid (Aβ) is involved in its pathogenesis …
between production and clearance of β‐amyloid (Aβ) is involved in its pathogenesis …
Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in lipopolysaccharide-induced neuroinflammation
J Wang, B Liu, F Sun, Y Xu, H Luan, M Yang… - International …, 2022 - Elsevier
Adult neurogenesis in hippocampus dentate gyrus (DG) is associated with numerous
neurodegenerative diseases such as aging and Alzheimer's disease (AD). Overactivation of …
neurodegenerative diseases such as aging and Alzheimer's disease (AD). Overactivation of …
Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks
FS Menniti, CW Lindsley… - Current topics in …, 2013 - ingentaconnect.com
Schizophrenia is a highly debilitating mental disorder which afflicts approximately 1% of the
global population. Cognitive and negative deficits account for the lifelong disability …
global population. Cognitive and negative deficits account for the lifelong disability …
A novel negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors inhibits synaptic transmission in hippocampal interneurons
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate
excitatory synaptic transmission and have been implicated in numerous neurological …
excitatory synaptic transmission and have been implicated in numerous neurological …
[CITATION][C] Identification and characterization of novel NMDA receptor antagonists selective for NR2A-over NR2B-containing receptors
E Bettini, A Sava, C Griffante, C Carignani… - … of Pharmacology and …, 2010 - ASPET