Cellular interactions with the extracellular matrix and with neighboring cells profoundly
influence a variety of signaling events including those involved in mitogenesis, survival, and …

Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

The identification of MHC class II restricted peptide epitopes is an important goal in
immunological research. A number of computational tools have been developed for this …

Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. This
explains why podocyte injury is typically associated with nephrotic syndrome. The present …

Polycomb group protein Ezh2, one of the key regulators of development in organisms from
flies to mice, exerts its epigenetic function through regulation of histone methylation. Here …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

The innate immune response is crucial for defense against microbial pathogens. To
investigate the molecular choreography of this response, we carried out a systematic …

Helicobacter pylori toxin, VacA, damages the gastric epithelium by erosion and loosening of
tight junctions. Here we report that VacA also interferes with T cell activation by two different …

The T-cell receptor (TCR) signalling machinery is central in determining the response of a T
cell (establishing immunity or tolerance) following exposure to antigen. This process is made …