HMGB1 in health and disease
R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao… - Molecular aspects of …, 2014 - Elsevier
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
Pyroptosis and its role in autoimmune disease: a potential therapeutic target
R You, X He, Z Zeng, Y Zhan, Y **ao… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases are a group of heterogeneous diseases with diverse clinical
manifestations that can be divided into systemic and organ-specific. The common etiology of …
manifestations that can be divided into systemic and organ-specific. The common etiology of …
The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases
M Magna, DS Pisetsky - Molecular medicine, 2014 - Springer
High-mobility group box 1 (HMGB1) protein is a highly abundant protein that can promote
the pathogenesis of inflammatory and autoimmune diseases once it is in an extracellular …
the pathogenesis of inflammatory and autoimmune diseases once it is in an extracellular …
[HTML][HTML] Targeting HMGB1: A potential therapeutic strategy for chronic kidney disease
T Liu, Q Li, Q **, L Yang, H Mao, P Qu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
High-mobility group protein box 1 (HMGB1) is a member of a highly conserved high-mobility
group protein present in all cell types. HMGB1 plays multiple roles both inside and outside …
group protein present in all cell types. HMGB1 plays multiple roles both inside and outside …
Alarmins in autoimmune diseases
MG Danieli, E Antonelli, MA Piga, I Claudi… - Autoimmunity …, 2022 - Elsevier
Alarmins are endogenous, constitutively expressed, chemotacting and immune activating
proteins or peptides released because of non-programmed cell death (ie infections, trauma …
proteins or peptides released because of non-programmed cell death (ie infections, trauma …
Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases
Neutrophils are the most abundant leukocytes in circulation and represent one of the first
lines of defense against invading pathogens. Neutrophils possess a vast arsenal of …
lines of defense against invading pathogens. Neutrophils possess a vast arsenal of …
[HTML][HTML] The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases
Q Chen, X Guan, X Zuo, J Wang, W Yin - Acta Pharmaceutica Sinica B, 2016 - Elsevier
High mobility group box 1 (HMGB1) is a nuclear protein that can bind to DNA and act as a co-
factor for gene transcription. When released into extracellular fluid, it plays a …
factor for gene transcription. When released into extracellular fluid, it plays a …
HMGB1 and repair: focus on the heart
L Pellegrini, E Foglio, E Pontemezzo, A Germani… - Pharmacology & …, 2019 - Elsevier
High-mobility group box 1 (HMGB1) is one of the most abundant proteins in eukaryotes and
the best characterized damage-associated molecular pattern (DAMP). The biological …
the best characterized damage-associated molecular pattern (DAMP). The biological …
[HTML][HTML] Urinary biomarkers in lupus nephritis
CC Aragón, RA Tafúr, A Suárez-Avellaneda… - Journal of translational …, 2020 - Elsevier
Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease that can affect
any organ of the body. Multiple mechanisms may contribute to the pathophysiology of …
any organ of the body. Multiple mechanisms may contribute to the pathophysiology of …
Macrophage depletion ameliorates nephritis induced by pathogenic antibodies
Abstract Kidney involvement affects 40–60% of patients with lupus, and is responsible for
significant morbidity and mortality. Using depletion approaches, several studies have …
significant morbidity and mortality. Using depletion approaches, several studies have …