Permanent fibrosis and chronic deterioration of heart function in patients after myocardial
infarction present a major health-care burden worldwide. In contrast to the restricted …

Successful progression from bench to bedside for regenerative medicine products is
challenging and requires a multidisciplinary approach. What has not yet been fully …

Repairing injured tissues/organs is one of the major challenges for the maintenance of
proper organ function in adulthood. In mammals, the central nervous system including the …

The axonal growth‐restrictive character of traumatic spinal cord injury (SCI) makes finding a
therapeutic strategy a very demanding task, due to the postinjury events impeditive to …

Large-scale regeneration in the adult central nervous system is a unique capacity of
salamanders among tetrapods. Salamanders can replace neuronal populations, repair …

Axolotls are uniquely able to resolve spinal cord injuries, but little is known about the
mechanisms underlying spinal cord regeneration. We previously found that tail amputation …

Visualizing, tracking and reconstructing cell lineages in develo** embryos has been an
ongoing effort for well over a century. Recent advances in light microscopy, labelling …

In the develo** nervous system, neural stem cells are polarized and maintain an apical
domain facing a central lumen. The presence of apical membrane is thought to have a …

Tissue regeneration requires precise temporal control of cellular processes such as
inflammatory signaling, chromatin remodeling and proliferation. The combination of these …

Xenopus tadpoles have the ability to regenerate their tails upon amputation. Although some
of the molecular and cellular mechanisms that globally regulate tail regeneration have been …