Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …

Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …

Cell death is an important part of the life cycle, serving as a foundation for both the orderly
development and the maintenance of physiological equilibrium within organisms. This …

Cysteine is required for synthesis of glutathione (GSH), coenzyme A, other sulfur-containing
metabolites, and most proteins. In most cells, cysteine comes from extracellular disulfide …

Abstract TXNL1 (also named TRP32, for thioredoxin related protein of 32 kDa) is a cytosolic
thioredoxin-fold protein expressed in all cell types and conserved from yeast to mammals …

Approximately 50%–55% of high-grade serous ovarian carcinoma (HGSOC) patients have
MYC oncogenic pathway activation. Because MYC is not directly targetable, we have …

Sepsis is a common complication of infections that significantly impacts the survival of
critically patients. Currently, effective pharmacological treatment strategies are lacking …

Simple Summary Glioblastoma (GBM) is a fatal brain cancer. Over 50% of GBM tumors
overexpress EGFR, a protein involved in tumor progression and drug resistance. The …