The cortisol switch between vulnerability and resilience
In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …
[HTML][HTML] Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders
Here we discuss the role of diverse environmental manipulations affecting cognition with
special regard to psychiatric conditions. We present evidence supporting a direct causal …
special regard to psychiatric conditions. We present evidence supporting a direct causal …
Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice
The brain and behavior are under energetic constraints, limited by mitochondrial energy
transformation capacity. However, the mitochondria-behavior relationship has not been …
transformation capacity. However, the mitochondria-behavior relationship has not been …
[HTML][HTML] A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study
C Kelly, C Trumpff, C Acosta, S Assuras, J Baker… - Trends in Endocrinology …, 2024 - cell.com
Health emerges from coordinated psychobiological processes powered by mitochondrial
energy transformation. But how do mitochondria regulate the multisystem responses that …
energy transformation. But how do mitochondria regulate the multisystem responses that …
Mitochondrial dynamics and psychiatric disorders: The missing link
Elucidating the molecular mechanisms of psychopathology is crucial for optimized diagnosis
and treatment. Accumulating literature has underlined how mitochondrial bioenergetics …
and treatment. Accumulating literature has underlined how mitochondrial bioenergetics …
Forced swim stressor: Trends in usage and mechanistic consideration
The acquired immobility response during the “forced swim test (FST)” is not a rodent model
of depression, but the test has some validity in predicting a compound's antidepressant …
of depression, but the test has some validity in predicting a compound's antidepressant …
The acute stress response in the multiomic era
Studying the stress response is a major pillar of neuroscience research not only because
stress is a daily reality but also because the exquisitely fine-tuned bodily changes triggered …
stress is a daily reality but also because the exquisitely fine-tuned bodily changes triggered …
Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response
T Santos-Silva, D Hazar Ülgen, CFB Lopes… - Translational …, 2023 - nature.com
Adolescent individuals exhibit great variability in cortical dynamics and behavioral
outcomes. The develo** adolescent brain is highly sensitive to social experiences and …
outcomes. The develo** adolescent brain is highly sensitive to social experiences and …
Whole blood mitochondrial copy number in clinical populations with mood disorders: A meta-analysis: Blood mitochondrial copy number and mood disorders
Major depressive disorder (MDD) and bipolar disorder (BD), are globally prevalent,
contributing to significant disease burden and adverse health outcomes. These mood …
contributing to significant disease burden and adverse health outcomes. These mood …
Glucocorticoids, metabolism and brain activity
A Jaszczyk, GR Juszczak - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
The review integrates different experimental approaches including biochemistry, c-Fos
expression, microdialysis (glutamate, GABA, noradrenaline and serotonin) …
expression, microdialysis (glutamate, GABA, noradrenaline and serotonin) …