Harnessing big data to characterize immune-related adverse events
Immune-checkpoint inhibitors (ICIs) have transformed patient care in oncology but are
associated with a unique spectrum of organ-specific inflammatory toxicities known as …
associated with a unique spectrum of organ-specific inflammatory toxicities known as …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Leveraging systems immunology to optimize diagnosis and treatment of inborn errors of immunity
Inborn errors of immunity (IEI) are monogenic disorders that can cause diverse symptoms,
including recurrent infections, autoimmunity and malignancy. While many factors have …
including recurrent infections, autoimmunity and malignancy. While many factors have …
SRTdb: an omnibus for human tissue and cancer-specific RNA transcripts
Q Shi, T Liu, W Hu, Z Chen, X He, S Li - Biomarker Research, 2022 - Springer
The production of functional mature RNA transcripts from genes undergoes various pre-
transcriptional regulation and post-transcriptional modifications. Accumulating studies …
transcriptional regulation and post-transcriptional modifications. Accumulating studies …
Statistical framework for calling allelic imbalance in high-throughput sequencing data
High-throughput sequencing facilitates large-scale studies of gene regulation and allows
tracing the associations of individual genomic variants with changes in gene expression …
tracing the associations of individual genomic variants with changes in gene expression …
Merging iPSCs and “omics”: Advances in the field and potential applications to untangle neurodegenerative diseases
L Streubel-Gallasch, P Seibler - Integrative Omics in Parkinson's Disease, 2025 - Elsevier
Human induced pluripotent stem cells (iPSCs) represent an unparalleled and unlimited
resource of patient-specific cells that can be directed into the diseased cell type. Combining …
resource of patient-specific cells that can be directed into the diseased cell type. Combining …