Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

This article aims to alert the medical community and public health authorities to
accumulating evidence on health benefits from sun exposure, which suggests that …

Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location.
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …

Preclinical studies have suggested that epigenetic therapy could enhance immunogenicity
of cancer cells. We report the results of the PEMDAC phase 2 clinical trial (n= 29; …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Recent developments in oncology have led to a better molecular and cellular understanding
of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare …

Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …