The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Alzheimer's disease (AD) is the most common neurodegenerative disease. Pathological
proteins of AD mainly contain amyloid-beta (Aβ) and tau. Their deposition will lead to neuron …

It has been suggested that exercise training and probiotic supplementation could decelerate
the progress of functional and biochemical deterioration in APP/PS1 transgenic mice …

Emerging evidence suggests that vascular pathological changes play a pivotal role in the
pathogenesis of Alzheimer's disease (AD). The dysfunction of the cerebral vasculature …

Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its
control over leukocyte-mediated immune responses. However, it is now recognized that …

With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Extracellular vesicles (EVs) including plasma membrane–derived microvesicles and
endosomal-derived exosomes aggregate by unknown mechanisms, forming …

Innovative therapeutic strategies are urgently needed for Alzheimer's disease (AD) due to
the increasing size of the aging population and the lack of effective drug treatment. Here, we …

Annexin-A1 (ANXA1) was first discovered in the early 1980's as a protein, which mediates
(some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 …

Annexin‐A1 has a well‐defined anti‐inflammatory role in the innate immune system, but its
function in adaptive immunity remains controversial. This glucocorticoid‐induced protein has …