Adaptive homeostasis is “the transient expansion or contraction of the homeostatic range for
any given physiological parameter in response to exposure to sub‐toxic, non‐damaging …

Use of microscopic computed-tomography (micro-CT) scanning continues to grow in
biomedical research. Laboratory-based micro-CT scanners, laboratory-based nano-CT …

Importance of the field: Effective vascularization of thick three-dimensional engineered
tissue constructs is a problem in tissue engineering. As in native organs, a tissue …

The kidney is faced with unique challenges for oxygen regulation, both because its function
requires that perfusion greatly exceeds that required to meet metabolic demand and …

It has been suggested that the big questions of science are answered–that science has
entered a “twilight age” where all the important knowledge is known and only the details …

Per gram of tissue, the kidneys are among our most highly perfused organs. Yet the renal
cortex and, in particular, the renal medulla are susceptible to hypoxia. In turn, hypoxia is a …

Background Micro-CT is a novel X-ray imaging modality which can provide 3D high
resolution images of the vascular network filled with contrast agent. The cerebrovascular …

The rising number of patients needing renal replacement therapy, alongside the significant
clinical and economic limitations of current therapies, creates an imperative need for new …

Super-resolution ultrasound imaging (SRUS) enables in vivo microvascular imaging of
deeper-lying tissues and organs, such as the kidneys or liver. The technique allows new …

There is a need for, and utility in, the acquisition of data sets of cardiac histoanatomy, with
the vision of reconstructing individual hearts on the basis of noninvasive imaging, such as …