Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

Fungal endocarditis: pathophysiology, epidemiology, clinical presentation, diagnosis, and management

GR Thompson III, JD Jenks, JW Baddley… - Clinical microbiology …, 2023 - journals.asm.org
Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated
with high morbidity and mortality (> 70%), and presents numerous challenges during clinical …

[HTML][HTML] Pulmonary aspergillosis: diagnosis and treatment

F Lamoth, T Calandra - European Respiratory Review, 2022 - publications.ersnet.org
Aspergillus species are the most frequent cause of fungal infections of the lungs with a
broad spectrum of clinical presentations including invasive pulmonary aspergillosis (IPA) …

Potential airborne human pathogens: A relevant inhabitant in built environments but not considered in indoor air quality standards

E Carrazana, T Ruiz-Gil, S Fujiyoshi, D Tanaka… - Science of The Total …, 2023 - Elsevier
Potential airborne human pathogens (PAHPs) may be a relevant component of the air
microbiome in built environments. Despite that PAHPs can cause infections, particularly in …

Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public …

A Langfeldt, JAW Gold, T Chiller - Current Clinical Microbiology Reports, 2022 - Springer
Abstract Purpose of Review For this review, we use a One Health approach to examine two
globally emerging public health threats related to antifungal drug resistance: triazole …

[HTML][HTML] Ibrexafungerp, a novel triterpenoid antifungal in development for the treatment of mold infections

DA Angulo, B Alexander, R Rautemaa-Richardson… - Journal of Fungi, 2022 - mdpi.com
Molds are ubiquitous in the environment, and immunocompromised patients are at
substantial risk of morbidity and mortality due to their underlying disease and the resistance …

[HTML][HTML] Outbreaks of fungal infections in hospitals: epidemiology, detection, and management

AP Douglas, AG Stewart, CL Halliday, SCA Chen - Journal of Fungi, 2023 - mdpi.com
Nosocomial clusters of fungal infections, whilst uncommon, cannot be predicted and are
associated with significant morbidity and mortality. Here, we review reports of nosocomial …

[HTML][HTML] Drug-Resistant Aspergillus spp.: A Literature Review of Its Resistance Mechanisms and Its Prevalence in Europe

MA De Francesco - Pathogens, 2023 - mdpi.com
Infections due to the Aspergillus species constitute an important challenge for human health.
Invasive aspergillosis represents a life-threatening disease, mostly in patients with immune …

Cyclic peptides with antifungal properties derived from bacteria, fungi, plants, and synthetic sources

NM Helmy, K Parang - Pharmaceuticals, 2023 - mdpi.com
Fungal infections remain a significant concern for human health. The emergence of
microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic …

Addressing microbial resistance worldwide: challenges over controlling life-threatening fungal infections

L Martins-Santana, CP Rezende, A Rossi… - Pathogens, 2023 - mdpi.com
Fungal infections are a serious global concern because of their ability to spread and
colonize host tissues in immunocompromised individuals. Such infections have been …