Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

E Marzetti, R Calvani, M Cesari, TW Buford… - The international journal …, 2013 - Elsevier
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

Protein damage, repair and proteolysis

N Chondrogianni, I Petropoulos, S Grimm… - Molecular aspects of …, 2014 - Elsevier
Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

The FSHD atrophic myotube phenotype is caused by DUX4 expression

C Vanderplanck, E Ansseau, S Charron, N Stricwant… - PloS one, 2011 - journals.plos.org
Background Facioscapulohumeral muscular dystrophy (FSHD) is linked to deletions in 4q35
within the D4Z4 repeat array in which we identified the dou ble homeobo x 4 (DUX4) gene …

Association of thyroid function with sarcopenia in elderly Chinese euthyroid subjects

Y Sheng, D Ma, Q Zhou, L Wang, M Sun… - Aging clinical and …, 2019 - Springer
Objectives With the increase in aging population worldwide, the incidence of sarcopenia is
also increasing. Thyroid hormones are important regulators that can affect body composition …

The aging thyroid: a reappraisal within the geroscience integrated perspective

C Franceschi, R Ostan, S Mariotti, D Monti… - Endocrine …, 2019 - academic.oup.com
The thyroid plays a crucial and pervasive role in physiology (metabolism, thermogenesis,
and immunity, among others) and its aging and related changes in thyroid hormone …

Coordination of mitochondrial biogenesis by thyroid hormone

JM Weitzel, KA Iwen - Molecular and cellular endocrinology, 2011 - Elsevier
Thyroid hormone (TH) has profound influence on metabolism that is closely linked to its
effect on mitochondrial biogenesis and function. After a single injection of TH into mammals …

Thyroid hormone action in muscle atrophy

MA De Stefano, R Ambrosio, T Porcelli, G Orlandino… - Metabolites, 2021 - mdpi.com
Skeletal muscle atrophy is a condition associated with various physiological and
pathophysiological conditions, such as denervation, cachexia, and fasting. It is characterized …

[HTML][HTML] Thyroid hormones play role in sarcopenia and myopathies

FF Bloise, TS Oliveira, A Cordeiro… - Frontiers in …, 2018 - frontiersin.org
Skeletal muscle maintains posture and enables movement by converting chemical energy
into mechanical energy, further contributing to basal energy metabolism. Thyroid hormones …

Thyroid function and sarcopenia: results from the ELSA‐Brasil study

C Szlejf, CK Suemoto, CCPS Janovsky… - Journal of the …, 2020 - Wiley Online Library
OBJECTIVES We aimed to investigate the association of subclinical thyroid disease and
thyroid hormone levels with sarcopenia and its defining components in community‐dwelling …

An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism

P Berbel, D Navarro, GC Román - Frontiers in endocrinology, 2014 - frontiersin.org
The morphological alterations of cortical lamination observed in mouse models of
developmental hypothyroidism prompted the recognition that these experimental changes …