Advances in stem cell research and therapeutic development
Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …
disorders or severe injuries, the number of proven stem cell therapies has remained small …
Stem cells in the treatment of disease
HM Blau, GQ Daley - New England Journal of Medicine, 2019 - Mass Medical Soc
Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …
Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …
immature, but this is improved by incorporation into engineered tissues or forced contraction …
Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …
understanding of how these disorders originate is limited by our ability to model the human …
3D cardiac cell culture: a critical review of current technologies and applications
C Zup**er - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Three-dimensional (3D) cell culture is often mentioned in the context of regenerative
medicine, for example, for the replacement of ischemic myocardium with tissue-engineered …
medicine, for example, for the replacement of ischemic myocardium with tissue-engineered …
Human engineered heart tissue models for disease modeling and drug discovery
The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
Cardiac tissues from stem cells: new routes to maturation and cardiac regeneration
The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …
opportunities to study disease and produce cells that can be used for therapy in …
hiPSCs derived cardiac cells for drug and toxicity screening and disease modeling: what micro-electrode-array analyses can tell us
S Kussauer, R David, H Lemcke - Cells, 2019 - mdpi.com
Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CM) have been
intensively used in drug development and disease modeling. Since iPSC-cardiomyocyte …
intensively used in drug development and disease modeling. Since iPSC-cardiomyocyte …
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia
G Campostrini, G Kosmidis… - Cardiovascular …, 2023 - academic.oup.com
Aims Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to
study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium …
study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium …
[HTML][HTML] Engineered models of the human heart: directions and challenges
Human heart (patho) physiology is now widely studied using human pluripotent stem cells,
but the immaturity of derivative cardiomyocytes has largely limited disease modeling to …
but the immaturity of derivative cardiomyocytes has largely limited disease modeling to …