Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate
recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive …

Infection of cells by microorganisms activates the inflammatory response. The initial sensing
of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll …

In terms of both phenotype and function, macrophages have remarkable heterogeneity,
which reflects the specialization of tissue-resident macrophages in microenvironments as …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …