T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …

Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …

Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …

γδ T cells, αβ T cells, and B cells are present together in all but the most primitive
vertebrates, suggesting that each population contributes to host immune competence …

The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines
following T cell receptor (TCR) activation and can shape the immune response in many …

A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …

The T cell repertoire comprises αβ and γδ T cell lineages. Although it is established how αβ
T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting …

The γδ T cell lineage in humans remains much of an enigma due to the low number of
defined antigens, the non-canonical ways in which these cells respond to their environment …