Alleles that introgress between species can influence the evolutionary and ecological fate of
species exposed to novel environments. Hybrid offspring of different species are often unfit …

In the past decade, advances in genome sequencing have allowed researchers to uncover
the history of hybridization in diverse groups of species, including our own. Although the …

Meiotic crossovers are limited in number and are prevented from occurring close to each
other by crossover interference. In many species, crossover number is subject to sexual …

Meiotic recombination is a fundamental feature of sexually reproducing species. It is often
required for proper chromosome segregation and plays important role in adaptation and the …

Now updated for its second edition, Population Genetics is the classic, accessible
introduction to the concepts of population genetics. Combining traditional conceptual …

Neutral theory predicts that genetic diversity increases with population size, yet observed
levels of diversity across metazoans vary only two orders of magnitude while population …

Engineering cellular phenotypes often requires the regulation of many genes. When using
CRISPR interference, coexpressing many single-guide RNAs (sgRNAs) triggers genetic …

Allopolyploids result from hybridization between different evolutionary lineages coupled with
genome doubling. Homoeologous chromosomes (chromosomes with common shared …

Abstract p53 is a potent tumor suppressor and commonly mutated in human cancers.
Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline …

Recombination is a central biological process with implications for many areas in the life
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …