Management of treatment-resistant depression: challenges and strategies
Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …
which does not respond to traditional and first-line therapeutic options. There are several …
Clinical research challenges posed by difficult-to-treat depression
Approximately one-third of individuals in a major depressive episode will not achieve
sustained remission despite multiple, well-delivered treatments. These patients experience …
sustained remission despite multiple, well-delivered treatments. These patients experience …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
[HTML][HTML] Clinical outcomes in a large registry of patients with major depressive disorder treated with Transcranial Magnetic Stimulation
Background Randomized clinical trials have demonstrated that Transcranial Magnetic
Stimulation (TMS) is an effective treatment for episodes of major depressive disorder (MDD) …
Stimulation (TMS) is an effective treatment for episodes of major depressive disorder (MDD) …
Home-use transcranial direct current stimulation for the treatment of a major depressive episode: a randomized clinical trial
L Borrione, BA Cavendish, LVM Aparicio… - JAMA …, 2024 - jamanetwork.com
Importance Transcranial direct current stimulation (tDCS) is moderately effective for
depression when applied by trained staff. It is not known whether self-applied tDCS …
depression when applied by trained staff. It is not known whether self-applied tDCS …
A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N, N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression
JT Reckweg, CJ van Leeuwen, C Henquet… - Frontiers in …, 2023 - frontiersin.org
Background Treatment-resistant depression (TRD) is a substantial public health burden, but
current treatments have limited effectiveness. The aim was to investigate the safety and …
current treatments have limited effectiveness. The aim was to investigate the safety and …
Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression
Intravenous ketamine is posited to rapidly reverse depression by rapidly enhancing
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …
Accelerated intermittent theta-burst stimulation and treatment-refractory bipolar depression: a randomized clinical trial
Importance Bipolar disorder (BD) is chronic and disabling, with depression accounting for
the majority of time with illness. Recent research demonstrated a transformative advance in …
the majority of time with illness. Recent research demonstrated a transformative advance in …
[HTML][HTML] Dosing transcranial magnetic stimulation in major depressive disorder: relations between number of treatment sessions and effectiveness in a large patient …
Background The number of sessions in an acute TMS course for major depressive disorder
(MDD) is greater than in the earlier randomized controlled trials. Objective To compare …
(MDD) is greater than in the earlier randomized controlled trials. Objective To compare …
Annual Research Review: Defining and treating pediatric treatment‐resistant depression
Background Adolescent major depressive disorder (MDD) is a significant health problem,
associated with substantial morbidity, cost, and mortality. Depression is a significant risk …
associated with substantial morbidity, cost, and mortality. Depression is a significant risk …