Histopathological grading of epithelial dysplasia remains the principal laboratory method for
assessing the risk of malignant transformation in oral potentially malignant disorders …

Spontaneously occurring mutations accumulate in somatic cells throughout a person's
lifetime. The majority of these mutations do not have a noticeable effect, but some can alter …

Human epithelial tissues accumulate cancer-driver mutations with age,,,,,,,–, yet tumour
formation remains rare. The positive selection of these mutations suggests that they alter the …

Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …

The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin)
is 17-fold lower in Singapore than the UK,–, despite Singapore receiving 2–3 times more …

Subclonal architectures are prevalent across cancer types. However, the temporal
evolutionary dynamics that produce tumor subclones remain unknown. Here we measure …

In adult tissues, an exquisite balance exists between stem cell proliferation and the
generation of differentiated offspring. Classically, it has been argued that this balance is …

The skin is a classical example of a tissue maintained by stem cells. However, the identity of
the stem cells that maintain the interfollicular epidermis and the source of the signals that …