[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin
K Sandvig, B Van Deurs - Physiological reviews, 1996 - journals.physiology.org
Protein toxins such as ricin and Shiga toxin with intracellular targets have to be endocytosed
and translocated to the cytosol to inhibit the protein synthesis and thereby kill the cell. Ricin …
and translocated to the cytosol to inhibit the protein synthesis and thereby kill the cell. Ricin …
The coated pit and macropinocytic pathways serve distinct endosome populations
Clathrin-coated vesicle endocytosis and macropinocytosis are distinct endocytic pathways
demonstrable in several cell types including human epidermoid A431 cells (West, MA, MS …
demonstrable in several cell types including human epidermoid A431 cells (West, MA, MS …
Delivery into cells: lessons learned from plant and bacterial toxins
K Sandvig, B Van Deurs - Gene therapy, 2005 - nature.com
A number of protein toxins of bacterial and plant origin have cytosolic targets, and
knowledge about these toxins have provided us with essential information about …
knowledge about these toxins have provided us with essential information about …
Golgicide A reveals essential roles for GBF1 in Golgi assembly and function
Abstract ADP ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and
membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine …
membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine …
ARF1 is directly involved in dynamin-independent endocytosis
Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid
phase takes place primarily through a dynamin-and clathrin-independent, Cdc42-regulated …
phase takes place primarily through a dynamin-and clathrin-independent, Cdc42-regulated …
Ricin: mechanisms of cytotoxicity
MJ Lord, NA Jolliffe, CJ Marsden, CSC Pateman… - Toxicological …, 2003 - Springer
Ricin is a heterodimeric protein produced in the seeds of the castor oil plant (Ricinus
communis). It is exquisitely potent to mammalian cells, being able to fatally disrupt protein …
communis). It is exquisitely potent to mammalian cells, being able to fatally disrupt protein …
Membrane traffic exploited by protein toxins
K Sandvig, B Van Deurs - Annual review of cell and …, 2002 - annualreviews.org
▪ Abstract A large number of protein toxins having enzymatically active A-and B-moieties that
bind to cell surface receptors must be endocytosed before the A-moiety is translocated into …
bind to cell surface receptors must be endocytosed before the A-moiety is translocated into …
Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease
CS Chen, G Bach, RE Pagano - Proceedings of the …, 1998 - National Acad Sciences
Mucolipidosis, type IV (ML-IV) is an autosomal recessive storage disease that is
characterized by lysosomal accumulation of sphingolipids, phospholipids, and acid …
characterized by lysosomal accumulation of sphingolipids, phospholipids, and acid …
Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery
A Widera, F Norouziyan, WC Shen - Advanced drug delivery reviews, 2003 - Elsevier
Transferrin receptor has been an important protein for many of the advances made in
understanding the intricacies of the intramolecular sorting pathways of endocytosed …
understanding the intricacies of the intramolecular sorting pathways of endocytosed …