Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
Selection of chronic hepatitis B therapy with high barrier to resistance
Antiviral drug resistance is a crucial factor that frequently determines the success of long-
term therapy for chronic hepatitis B. The development of resistance to nucleos (t) ide …
term therapy for chronic hepatitis B. The development of resistance to nucleos (t) ide …
[PDF][PDF] Impact of hepatitis B virus (HBV) preS/S genomic variability on HBV surface antigen and HBV DNA serum levels
T Pollicino, G Amaddeo, A Restuccia, G Raffa… - …, 2012 - Wiley Online Library
To evaluate whether hepatitis B virus (HBV) preS/S gene variability has any impact on
serum hepatitis B surface antigen (HBsAg) levels and to analyze the replication capacity of …
serum hepatitis B surface antigen (HBsAg) levels and to analyze the replication capacity of …
Care of HIV patients with chronic hepatitis B: updated recommendations from the HIV-Hepatitis B Virus International Panel
Nearly 10% of the estimated 36 million people having HIV worldwide suffer from chronic
hepatitis B virus (HBV) infection. The advent of new antiviral agents against HBV and the …
hepatitis B virus (HBV) infection. The advent of new antiviral agents against HBV and the …
Hepatitis B virus escape mutants induced by antiviral therapy
The hepatitis B virus (HBV) polymerase and envelope genes overlap in such a way that
resistance mutations to antiviral agents in the reverse transcriptase gene may affect the …
resistance mutations to antiviral agents in the reverse transcriptase gene may affect the …
High prevalence of occult hepatitis B virus infection in children born to HBsAg-positive mothers despite prophylaxis with hepatitis B vaccination and HBIG
S Shahmoradi, Y Yahyapour, M Mahmoodi… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Occult hepatitis B virus (HBV) infection is a well-recognized clinical
entity characterized by the detection of HBV DNA in serum and/or liver in the absence of …
entity characterized by the detection of HBV DNA in serum and/or liver in the absence of …
[HTML][HTML] Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression
The annual number of deaths caused by hepatitis B virus (HBV)-related disease, including
cirrhosis and hepatocellular carcinoma (HCC), is estimated as 887000. The reported …
cirrhosis and hepatocellular carcinoma (HCC), is estimated as 887000. The reported …
Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients
BM Liu, T Li, J Xu, XG Li, JP Dong, P Yan, JX Yang… - Antiviral research, 2010 - Elsevier
Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and
sequenced among 192 nucleos (t) ide analogue (NA)-naïve Chinese patients with chronic …
sequenced among 192 nucleos (t) ide analogue (NA)-naïve Chinese patients with chronic …
HBsAg variants: diagnostic-escape and diagnostic dilemma
SM Alavian, WF Carman, SM Jazayeri - Journal of Clinical virology, 2013 - Elsevier
A wide variety of commercial assays is available for the detection of hepatitis B surface
antigen (HBsAg). Clearly, the sensitivity of an assay to detect a variant is dependent on the …
antigen (HBsAg). Clearly, the sensitivity of an assay to detect a variant is dependent on the …
[HTML][HTML] Clinical and virological significance of the co-existence of HBsAg and anti-HBs antibodies in hepatitis B chronic carriers
The co-existence of hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (HBsAb) in
serum of hepatitis B virus (HBV)-chronic carriers has been previously associated with …
serum of hepatitis B virus (HBV)-chronic carriers has been previously associated with …