Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association

JJ Joseph, P Deedwania, T Acharya, D Aguilar… - Circulation, 2022 - ahajournals.org
Cardiovascular disease remains the leading cause of death in patients with diabetes.
Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk …

Metabolic syndrome

IJ Neeland, S Lim, A Tchernof, A Gastaldelli… - Nature Reviews …, 2024 - nature.com
The metabolic syndrome (MetS) is a multiplex modifiable risk factor for cardiovascular
disease, type 2 diabetes mellitus and other health outcomes, and is a major challenge to …

[HTML][HTML] A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to …

M Safaei, EA Sundararajan, M Driss, W Boulila… - Computers in biology …, 2021 - Elsevier
Obesity is considered a principal public health concern and ranked as the fifth foremost
reason for death globally. Overweight and obesity are one of the main lifestyle illnesses that …

Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H **ao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Obesity, adipose tissue and vascular dysfunction

M Koenen, MA Hill, P Cohen, JR Sowers - Circulation research, 2021 - ahajournals.org
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

The cardio-renal-metabolic connection: a review of the evidence

M Marassi, GP Fadini - Cardiovascular Diabetology, 2023 - Springer
Abstract Type 2 diabetes (T2D), cardiovascular disease (CVD) and chronic kidney disease
(CKD), are recognized among the most disruptive public health issues of the current century …

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Hypertension management in patients with cardiovascular comorbidities

L Lauder, F Mahfoud, M Azizi, DL Bhatt… - European Heart …, 2023 - academic.oup.com
Arterial hypertension is a leading cause of death globally. Due to ageing, the rising
incidence of obesity, and socioeconomic and environmental changes, its incidence …

Macrophage polarization: an important role in inflammatory diseases

M Luo, F Zhao, H Cheng, M Su, Y Wang - Frontiers in immunology, 2024 - frontiersin.org
Macrophages are crucial cells in the human body's innate immunity and are engaged in a
variety of non-inflammatory reactions. Macrophages can develop into two kinds when …