Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding
RNA, play a crucial role in the regulation of gene expression and are pivotal in biological …

In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …

Histones are subject to a diverse array of post-translational modifications. Among them,
lysine acetylation is not only the most pervasive and dynamic modification but also highly …

Most factors that regulate gene transcription in eukaryotic cells are multimeric, often large,
protein complexes. The understanding of the biogenesis pathways of such large and …

Acetylation of histones is a key post-translational modification that guides gene expression
regulation. In yeast, the class I histone deacetylase containing Rpd3S complex plays a …

The Rpd3S complex plays a pivotal role in facilitating local histone deacetylation in the
transcribed regions to suppress intragenic transcription initiation. Here, we present the cryo …

Chromosomes must correctly fold in eukaryotic nuclei for proper genome function.
Eukaryotic organisms hierarchically organize their genomes, including in the fungus …

Acetylation of histones is a key post-translational modification that guides gene expression
regulation. In yeast, the class I histone deacetylase containing Rpd3S complex plays a …

Zn2+-dependent histone deacetylases (HDACs) are enzymes that regulate gene expression
by removing acetyl groups from histone proteins. These enzymes are essential in all living …

The Rpd3 histone deacetylase complex is a multiple-subunit complex that mediates the
regulation of chromatin accessibility and gene expression. Sin3, the largest subunit of Rpd3 …