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The role of regulatory variation in complex traits and disease
FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
Gene regulation and speciation
KL Mack, MW Nachman - Trends in Genetics, 2017 - cell.com
Understanding the genetic architecture of speciation is a major goal in evolutionary biology.
Hybrid dysfunction is thought to arise most commonly through negative interactions between …
Hybrid dysfunction is thought to arise most commonly through negative interactions between …
Genome evolution across 1,011 Saccharomyces cerevisiae isolates
J Peter, M De Chiara, A Friedrich, JX Yue, D Pflieger… - Nature, 2018 - nature.com
Large-scale population genomic surveys are essential to explore the phenotypic diversity of
natural populations. Here we report the whole-genome sequencing and phenoty** of …
natural populations. Here we report the whole-genome sequencing and phenoty** of …
A global genetic interaction network maps a wiring diagram of cellular function
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
Defining the consequences of genetic variation on a proteome-wide scale
Genetic variation modulates protein expression through both transcriptional and post-
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen
PK Strope, DA Skelly, SG Kozmin… - Genome …, 2015 - genome.cshlp.org
Saccharomyces cerevisiae, a well-established model for species as diverse as humans and
pathogenic fungi, is more recently a model for population and quantitative genetics. S …
pathogenic fungi, is more recently a model for population and quantitative genetics. S …
A high-definition view of functional genetic variation from natural yeast genomes
The question of how genetic variation in a population influences phenotypic variation and
evolution is of major importance in modern biology. Yet much is still unknown about the …
evolution is of major importance in modern biology. Yet much is still unknown about the …
Post-mortem molecular profiling of three psychiatric disorders
Background Psychiatric disorders are multigenic diseases with complex etiology that
contribute significantly to human morbidity and mortality. Although clinically distinct, several …
contribute significantly to human morbidity and mortality. Although clinically distinct, several …
The fascinating and secret wild life of the budding yeast S. cerevisiae
G Liti - Elife, 2015 - elifesciences.org
The budding yeast Saccharomyces cerevisiae has been used in laboratory experiments for
over a century and has been instrumental in understanding virtually every aspect of …
over a century and has been instrumental in understanding virtually every aspect of …
Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population
The manner by which genotype and environment affect complex phenotypes is one of the
fundamental questions in biology. In this study, we quantified the transcriptome—a subset of …
fundamental questions in biology. In this study, we quantified the transcriptome—a subset of …