IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …

Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …

Highlights•Actin polymerization on endosomes is primarily controlled by the regulation of the
WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and …

Osteoclasts are giant multinucleated myeloid cells specialized for bone resorption, which is
essential for the preservation of bone health throughout life. The activity of osteoclasts relies …

STUDY QUESTION Are genetic effects on endometrial gene expression tissue specific
and/or associated with reproductive traits and diseases? SUMMARY ANSWER Analyses of …

Blood platelets are produced by large bone marrow (BM) precursor cells, megakaryocytes
(MKs), which extend cytoplasmic protrusions (proplatelets) into BM sinusoids. The molecular …

Global increases in coral disease prevalence have been linked to ocean warming through
changes in coral‐associated bacterial communities, pathogen virulence and immune system …

Polypoidal choroidal vasculopathy (PCV), a subtype of'wet'age-related macular
degeneration (AMD), constitutes up to 55% of cases of wet AMD in Asian patients. In …

Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal
class III malocclusion. MP is a complex genetic trait, although familial recurrence also …

Pancreatic ductal adenocarcinoma (PDAC), cancer with a high mortality rate and the highest
rate of KRAS mutation, reportedly internalizes proteins via macropinocytosis to adapt to low …