Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that
utilize oxidative phosphorylation as the main metabolic pathway to produce energy. Copper …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …

Abstract p53 plays a key role in tumor suppression. The tumor suppressive function of p53
has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …

Metastasis represents one of the most dangerous issue of cancer progression, characterized
by intricate interactions between invading tumor cells, various proteins, and other cells on …

In recent years, progress in nanotechnology provided new tools to treat cancer more
effectively. Advances in biomaterials tailored for drug delivery have the potential to …

The TP53 tumor suppressor gene is the most frequently altered gene in tumors and an
increasing number of studies highlight that mutant p53 proteins can acquire oncogenic …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …