Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
X Tong, R Tang, M **ao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …
body against pathogenic substances. This process, called regulated cell death (RCD), is …
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
R Tang, J Xu, B Zhang, J Liu, C Liang, J Hua… - Journal of hematology & …, 2020 - Springer
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has
achieved considerable success in the clinic. However, ICIs are significantly limited by the …
achieved considerable success in the clinic. However, ICIs are significantly limited by the …
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
A guide to cell death pathways
J Yuan, D Ofengeim - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …
The role of necroptosis in cancer biology and therapy
Y Gong, Z Fan, G Luo, C Yang, Q Huang, K Fan… - Molecular cancer, 2019 - Springer
Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure
during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is …
during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is …
Pattern recognition receptors and the host cell death molecular machinery
GP Amarante-Mendes, S Adjemian, LM Branco… - Frontiers in …, 2018 - frontiersin.org
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns …
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns …
Necroptosis and tumor progression
Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …
Modes of regulated cell death in cancer
E Koren, Y Fuchs - Cancer discovery, 2021 - AACR
Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …
Necroptosis in development, inflammation and disease
R Weinlich, A Oberst, HM Beere… - Nature reviews Molecular …, 2017 - nature.com
In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …
molecule already recognized as an important regulator of cell survival, inflammation and …