The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but
how and for what purposes have been matters of much debate. In this review, we summarize …

Induced pluripotent stem cells are powerful tools for disease modeling, drug screening, and
cell transplantation therapies. These cells can be generated directly from somatic cells by …

The development of organs with an epithelial parenchyma relies on reciprocal
mesenchymal-epithelial communication. Mouse corneal epithelium stratification is the …

The technology to derive embryonic and induced pluripotent stem cells from early embryonic
stages and adult somatic cells, respectively, emerged as a powerful resource to enable the …

Human cell reprogramming remains extremely inefficient and the underlying mechanisms by
different reprogramming factors are elusive. We found that NANOG and LIN28 (NL) …

Over the last 2 decades, induced pluripotent stem cells (iPSCs) have had various potential
applications in various medical research areas, from personalized medicine to disease …

G protein-coupled receptors (GPCRs) are a large class of transmembrane receptors
categorized into five distinct families: rhodopsin, secretin, adhesion, glutamate, and frizzled …

Alkaline phosphatase (ALP) is a ubiquitous membrane-bound glycoprotein capable of
providing inorganic phosphate by catalyzing the hydrolysis of organic phosphate esters, or …

Background and objective: Hyperglycemia leads to adaptive cell responses in part due to
hyperosmolarity. In endothelial and epithelial cells, hyperosmolarity induces aquaporin-1 …