Neurofilaments and neurofilament proteins in health and disease
Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …
Post-translational modifications of intermediate filament proteins: mechanisms and functions
NT Snider, MB Omary - Nature reviews Molecular cell biology, 2014 - nature.com
Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …
Neurofilaments at a glance
Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of
neurons. Although they are present in perikarya and dendrites, neurofilaments are …
neurons. Although they are present in perikarya and dendrites, neurofilaments are …
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
The mRNA transcript of the human STMN2 gene, encoding for stathmin-2 protein (also
called SCG10), is profoundly impacted by TAR DNA-binding protein 43 (TDP-43) loss of …
called SCG10), is profoundly impacted by TAR DNA-binding protein 43 (TDP-43) loss of …
Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration
R Perrot, R Berges, A Bocquet, J Eyer - Molecular neurobiology, 2008 - Springer
Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …
axons from adult central and peripheral nervous system. Here, we provide an overview of …
Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm
Intermediate filaments (IFs) are cytoskeletal polymers whose protein constituents are
encoded by a large family of differentially expressed genes. Owing in part to their properties …
encoded by a large family of differentially expressed genes. Owing in part to their properties …
Functions of intermediate filaments in neuronal development and disease
RC Lariviere, JP Julien - Journal of neurobiology, 2004 - Wiley Online Library
Five major types of intermediate filament (IF) proteins are expressed in mature neurons: the
three neurofilament proteins (NF‐L, NF‐M, and NF‐H), α‐internexin, and peripherin. While …
three neurofilament proteins (NF‐L, NF‐M, and NF‐H), α‐internexin, and peripherin. While …
The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders
A Didonna, P Opal - Molecular neurodegeneration, 2019 - Springer
Many neurodegenerative disorders, including Parkinson's, Alzheimer's, and amyotrophic
lateral sclerosis, are well known to involve the accumulation of disease-specific proteins …
lateral sclerosis, are well known to involve the accumulation of disease-specific proteins …
'Heads and tails' of intermediate filament phosphorylation: multiple sites and functional insights
MB Omary, NO Ku, GZ Tao, DM Toivola… - Trends in biochemical …, 2006 - cell.com
Intermediate filaments (IFs) are major components of the mammalian cytoskeleton. They are
among the most abundant cellular phosphoproteins; their phosphorylation typically involves …
among the most abundant cellular phosphoproteins; their phosphorylation typically involves …
Intermediate filaments are dynamic and motile elements of cellular architecture
Recent evidence showing that intermediate filaments (IFs) are dynamic, motile elements of
the cytoskeletal repertoire of vertebrate cells has overturned the long-standing view that they …
the cytoskeletal repertoire of vertebrate cells has overturned the long-standing view that they …