Pig blastocyst–uterine interactions

FW Bazer, GA Johnson - Differentiation, 2014 - Elsevier
The litter-bearing pig is an invaluable model for research in reproductive biology. Spherical
pig blastocysts on Day 10 of pregnancy undergo rapid morphological changes to tubular …

Embryo‐maternal dialogue during pregnancy establishment and implantation in the pig

A Waclawik, MM Kaczmarek, A Blitek… - Molecular …, 2017 - Wiley Online Library
Porcine conceptuses secrete pregnancy‐recognition signals (estrogens, including estradiol‐
17β) that inhibit luteolysis, thereby prolonging progesterone production by corpora lutea …

Single-cell transcriptomic characterization of sheep conceptus elongation and implantation

GX Jia, WJ Ma, ZB Wu, S Li, XQ Zhang, Z He, SX Wu… - Cell Reports, 2023 - cell.com
Bidirectional communication between the develo** conceptus and endometrium is
essential for pregnancy recognition and establishment in ruminants. We dissect the …

MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity

S Altmäe, JA Martinez-Conejero… - Reproductive …, 2013 - journals.sagepub.com
MicroRNAs (miRNAs) act as important epigenetic posttranscriptional regulators of gene
expression. We aimed to gain more understanding of the complex gene expression …

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

A Fullár, J Dudás, L Oláh, P Hollósi, Z Papp, G Sobel… - BMC cancer, 2015 - Springer
Background Comparison of tissue microarray results of 29 cervical cancer and 27 normal
cervix tissue samples using immunohistochemistry revealed considerable reorganization of …

The early stages of implantation and placentation in the pig

GA Johnson, FW Bazer, H Seo - Placentation in Mammals: Tribute to EC …, 2021 - Springer
Pregnancy in pigs includes the events of conceptus (embryo/fetus and placental
membranes) elongation, implantation, and placentation. Placentation in pigs is defined …

Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep

GA Johnson, RC Burghardt, FW Bazer - Journal of animal science and …, 2014 - Springer
Osteopontin (OPN; also known as Secreted Phosphoprotein 1, SPP1) is a secreted extra-
cellular matrix (ECM) protein that binds to a variety of cell surface integrins to stimulate cell …

Research resource: interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks

S Altmäe, J Reimand, O Hovatta, P Zhang… - Molecular …, 2012 - academic.oup.com
A prerequisite for successful embryo implantation is adequate preparation of receptive
endometrium and the establishment and maintenance of a viable embryo. The success of …

Mechanisms for the establishment of pregnancy in the pig

AJ Ziecik, A Waclawik, MM Kaczmarek… - … in domestic animals, 2011 - Wiley Online Library
Contents Establishment of pregnancy in pigs requires continuous function of corpora lutea
and endometrial preparation for embryo implantation. Progesterone regulates expression of …

Interaction of the conceptus and endometrium to establish pregnancy in mammals: role of interleukin 1β

R Geisert, A Fazleabas, M Lucy, D Mathew - Cell and tissue research, 2012 - Springer
Implantation and the establishment of pregnancy in mammals involves an intricate interplay
of hormones, cytokines, growth factors, proteins, lipids, ions and the extracellular matrix …