Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
Biological properties of extracellular vesicles and their physiological functions
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …
Extracellular vesicles: biology and emerging therapeutic opportunities
S El Andaloussi, I Mäger, XO Breakefield… - Nature reviews Drug …, 2013 - nature.com
Within the past decade, extracellular vesicles have emerged as important mediators of
intercellular communication, being involved in the transmission of biological signals …
intercellular communication, being involved in the transmission of biological signals …
Exosome-based immunotherapy: a promising approach for cancer treatment
Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …
in the application of cell-released small vesicles that stimulate the immune system. As cell …
Exosomes in cancer: small particle, big player
X Zhang, X Yuan, H Shi, L Wu, H Qian, W Xu - Journal of hematology & …, 2015 - Springer
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …
In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior
Most cancer cells release heterogeneous populations of extracellular vesicles (EVs)
containing proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake …
containing proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake …
Exosomes and other extracellular vesicles in host–pathogen interactions
An effective immune response requires the engagement of host receptors by pathogen‐
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …
Exosomes and their roles in immune regulation and cancer
Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular
communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of …
communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of …
The role of exosomal PD-L1 in tumor progression and immunotherapy
F **e, M Xu, J Lu, L Mao, S Wang - Molecular cancer, 2019 - Springer
Programmed death ligand 1 (PD-L1), a type I transmembrane protein, binds to its receptor
PD-1 to suppress the activation of T cells, thereby maintaining immunological homeostasis …
PD-1 to suppress the activation of T cells, thereby maintaining immunological homeostasis …
Exosomes: new molecular targets of diseases
Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and
they perform as key regulators in cell-to-cell communication in normal as well as diseased …
they perform as key regulators in cell-to-cell communication in normal as well as diseased …