During the past decade a plethora of studies have unravelled the multiple roles of nitric
oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is …

There has recently been an explosion of interest in the analysis of breath constituents as a
way of monitoring inflammation and oxidative stress in the lungs. Here we review the use of …

The use of exhaled nitric oxide measurements (FEno) in clinical practice is now coming of
age. There are a number of theoretical and practical factors which have brought this about …

Analysis of various biomarkers in exhaled breath allows completely non-invasive monitoring
of inflammation and oxidative stress in the respiratory tract in inflammatory lung diseases …

COPD and asthma are important chronic inflammatory disorders with a high associated
morbidity. Much research has concentrated on the role of inflammatory cells, such as the …

Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second …

The complex nature of interactions between the pulmonary and cardiovascular systems is
becoming increasingly appreciated. Pulmonary vascular abnormalities are frequently …

Endogenous Nitric Oxide (NO) plays a key role in the physiological regulation of airway
functions. In response to various stimuli activated inflammatory cells (eg, eosinophils and …

The body constantly reacts with oxygen as part of the energy producing processes of cells.
Oxidative stress is a dysbalance between the production of free radicals as products of these …

Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, may be
associated with long-term airflow limitation. Survivors of BPD may develop asthma-like …