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Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
[HTML][HTML] Gut microbiome lipid metabolism and its impact on host physiology
Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …
recognition by the immune system and their influence on numerous metabolic pathways …
Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
[HTML][HTML] Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology
The intestine and liver are thought to metabolize dietary nutrients and regulate host nutrient
homeostasis. Here, we find that the gut microbiota also reshapes the host amino acid (aa) …
homeostasis. Here, we find that the gut microbiota also reshapes the host amino acid (aa) …
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …
altered gut microbiome. Our understanding of the underlying mechanisms has been …
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
Q Zhao, MY Dai, RY Huang, JY Duan, T Zhang… - Nature …, 2023 - nature.com
Parabacteroides distasonis (P. distasonis) plays an important role in human health,
including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that …
including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that …
Western diets and chronic diseases
Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism
The perinatal period represents a critical window for cognitive and immune system
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …
Applications of machine learning in metabolomics: Disease modeling and classification
Metabolomics research has recently gained popularity because it enables the study of
biological traits at the biochemical level and, as a result, can directly reveal what occurs in a …
biological traits at the biochemical level and, as a result, can directly reveal what occurs in a …
Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …