The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The intestine and liver are thought to metabolize dietary nutrients and regulate host nutrient
homeostasis. Here, we find that the gut microbiota also reshapes the host amino acid (aa) …

Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

Parabacteroides distasonis (P. distasonis) plays an important role in human health,
including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that …

Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …

The perinatal period represents a critical window for cognitive and immune system
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …

Metabolomics research has recently gained popularity because it enables the study of
biological traits at the biochemical level and, as a result, can directly reveal what occurs in a …

The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …