Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Red meat and processed meat consumption has been hypothesized to increase risk of
cancer, but the evidence is inconsistent. We performed a systematic review and meta …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Insulin resistance results when peripheral tissues, including adipose, skeletal muscle, and
liver, do not respond appropriately to insulin, causing the ineffective uptake of glucose. This …

Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

The coordinated regulation between cellular glucose uptake and endogenous glucose
production is indispensable for the maintenance of constant blood glucose concentrations …

During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Breast cancer is the cancer with the highest prevalence in women and is the number‐one
cause of cancer mortality worldwide. Cell transduction is a fundamental process in the …

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …