Cholangiocarcinoma 2020: the next horizon in mechanisms and management
JM Banales, JJG Marin, A Lamarca… - Nature reviews …, 2020 - nature.com
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
The emerging hallmarks of cancer metabolism
Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …
and indirect consequence of oncogenic mutations. A common feature of cancer cell …
Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study
GK Abou-Alfa, T Macarulla, MM Javle… - The Lancet …, 2020 - thelancet.com
Summary Background Isocitrate dehydrogenase 1 (IDH1) mutations occur in approximately
13% of patients with intrahepatic cholangiocarcinoma, a relatively uncommon cancer with a …
13% of patients with intrahepatic cholangiocarcinoma, a relatively uncommon cancer with a …
Comprehensive and integrative genomic characterization of hepatocellular carcinoma
A Ally, M Balasundaram, R Carlsen, E Chuah, A Clarke… - Cell, 2017 - cell.com
Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …
Cholangiocarcinoma—evolving concepts and therapeutic strategies
SI Ilyas, SA Khan, CL Hallemeier, RK Kelley… - Nature reviews Clinical …, 2018 - nature.com
Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features
of cholangiocyte differentiation: cholangiocarcinomas are categorized according to …
of cholangiocyte differentiation: cholangiocarcinomas are categorized according to …
Targeting mitochondrial metabolism for precision medicine in cancer
L Sainero-Alcolado, J Liaño-Pons… - Cell Death & …, 2022 - nature.com
During decades, the research field of cancer metabolism was based on the Warburg effect,
described almost one century ago. Lately, the key role of mitochondria in cancer …
described almost one century ago. Lately, the key role of mitochondria in cancer …
IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
Cholangiocarcinoma
Cholangiocarcinoma represents a diverse group of epithelial cancers united by late
diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are …
diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are …
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of …
JM Banales, V Cardinale, G Carpino… - Nature reviews …, 2016 - research.ed.ac.uk
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of
biliary tract differentiation. CCA is the second most common primary liver tumour and the …
biliary tract differentiation. CCA is the second most common primary liver tumour and the …
[HTML][HTML] Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma
Cholangiocarcinoma (CCA) comprises a heterogeneous group of cancers with pathologic
features of biliary tract differentiation, and is presumed to arise from the intra-or extrahepatic …
features of biliary tract differentiation, and is presumed to arise from the intra-or extrahepatic …