Background Hormone therapy (HT) is widely used for controlling menopausal symptoms
and has also been used for the management and prevention of cardiovascular disease …

Perimenopause marks the transition from a woman's reproductive stage to menopause.
Usually occurring between 42 and 52 years of age, it is determined clinically by the onset of …

ContextPostmenopausal women have a greater risk than men of develo** Alzheimer
disease, but studies of the effects of estrogen therapy on Alzheimer disease have been …

ContextThe Women's Health Initiative Memory Study (WHIMS) previously found increased
risk for dementia and no effect on mild cognitive impairment (MCI) in women treated with …

Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive
impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on …

ContextPrevious studies have shown a sex-specific increased risk of Alzheimer disease
(AD) in women older than 80 years. Basic neuroscience findings suggest that hormone …

Importance Most cognitive functions decline with age. Prior studies suggest that testosterone
treatment may improve these functions. Objective To determine if testosterone treatment …

ContextThe Women's Health Initiative Memory Study (WHIMS) previously reported that
estrogen plus progestin therapy does not protect cognition among women aged 65 years or …

ContextObservational studies have suggested that postmenopausal hormone treatment may
improve cognitive function, but data from randomized clinical trials have been sparse and …

ContextSome observational data suggest that hormone replacement therapy (HRT) may
reduce the risk of cognitive decline and dementia but results have been conflicting …