Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Z Lyu, Y Hu, Y Guo, D Liu - Bone research, 2023 - nature.com
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …

Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

YW Zhang, Y Wu, XF Liu, X Chen, JC Su - Ageing research reviews, 2024 - Elsevier
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass,
destruction of bone microstructure, raised bone fragility, and enhanced risk of fractures. The …

The microbiota-gut-bone axis and bone health

Y Tu, R Yang, X Xu, X Zhou - Journal of leukocyte biology, 2021 - academic.oup.com
The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria,
fungi, and viruses, known as the “second gene pool” of the human body. In recent years, the …

Gut microbiota and bone metabolism

L Lu, X Chen, Y Liu, X Yu - The FASEB Journal, 2021 - Wiley Online Library
Osteoporosis is the most common metabolic skeletal disease. It is characterized by the
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …

The rising era of “Immunoporosis”: Role of immune system in the pathophysiology of osteoporosis

RK Srivastava, L Sapra - Journal of Inflammation Research, 2022 - Taylor & Francis
Discoveries in the last few years have emphasized the existence of an enormous breadth of
communication between bone and the immune system in maintaining skeletal homeostasis …

[HTML][HTML] Living probiotic biomaterials for osteoporosis therapy

Z Chen, Z Cai, P Zhuang, F Li, W Cui, Z Li - Biomedical Technology, 2023 - Elsevier
Osteoporosis (OP) is a chronic metabolic bone disease characterized by diminished bone
mass, decreased bone strength, deterioration of bone microarchitecture, and increased …

Beneficial effect and mechanism of natural resourced polysaccharides on regulating bone metabolism through intestinal flora: A review

Y Zhou, YJ Sheng, CY Li, L Zou, CY Tong… - International Journal of …, 2023 - Elsevier
Bone metabolism is an important biological process for maintaining bone health.
Polysaccharides of natural origin exert beneficial effects on bone metabolism …

The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone

S Pal, DS Perrien, T Yumoto, R Faccio, A Stoica… - The Journal of Clinical …, 2022 - jci.org
Bone metastases are frequent complications of malignant melanoma leading to reduced
quality of life and significant morbidity. Regulation of immune cells by the gut microbiome …

Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis

RX Zhou, YW Zhang, MM Cao, CH Liu, YF Rui… - Journal of Bone and …, 2023 - Springer
Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low
bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically …

Adolescence and the microbiome: implications for healthy growth and maturation

MD Carson, C Westwater, CM Novince - The American Journal of …, 2023 - Elsevier
The gut microbiota was initially thought to develop into a stable, adult-like profile during
early postnatal life. The formation of the gut microbiota during early life has been shown to …