Why does obesity cause diabetes?

S Klein, A Gastaldelli, H Yki-Järvinen, PE Scherer - Cell metabolism, 2022 - cell.com
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Waist‐to‐height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta‐analysis

M Ashwell, P Gunn, S Gibson - Obesity reviews, 2012 - Wiley Online Library
Our aim was to differentiate the screening potential of waist‐to‐height ratio (WHtR) and waist
circumference (WC) for adult cardiometabolic risk in people of different nationalities and to …

Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management

IJ Neeland, P Poirier, JP Després - Circulation, 2018 - Am Heart Assoc
The prevalence of obesity has increased globally over the last 2 decades. Although the body
mass index has been a convenient and simple index of obesity at the population level …

European practical and patient-centred guidelines for adult obesity management in primary care

D Durrer Schutz, L Busetto, D Dicker… - Obesity facts, 2019 - karger.com
The first contact for patients with obesity for any medical treatment or other issues is
generally with General Practitioners (GPs). Therefore, given the complexity of the disease …

Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update

ME Piché, P Poirier, I Lemieux, JP Després - Progress in cardiovascular …, 2018 - Elsevier
Obesity is recognized as a heterogeneous condition in which individuals with similar body
mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to …

The gut microbiota and unhealthy aging: disentangling cause from consequence

EN DeJong, MG Surette, DME Bowdish - Cell Host & Microbe, 2020 - cell.com
The gut microbiota changes with age, but it is not clear to what degree these changes are
due to physiologic changes, age-associated inflammation or immunosenescence, diet …

[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

A new body shape index predicts mortality hazard independently of body mass index

NY Krakauer, JC Krakauer - PloS one, 2012 - journals.plos.org
Background Obesity, typically quantified in terms of Body Mass Index (BMI) exceeding
threshold values, is considered a leading cause of premature death worldwide. For given …

Central fatness and risk of all cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies

A Jayedi, S Soltani, MS Zargar, TA Khan, S Shab-Bidar - Bmj, 2020 - bmj.com
Objective To quantify the association of indices of central obesity, including waist
circumference, hip circumference, thigh circumference, waist-to-hip ratio, waist-to-height …