Through the study of transcriptional activation in response to interferon α (IFN-α) and
interferon γ (IFN-γ), a previously unrecognized direct signal transduction pathway to the …

Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects.
Because of these important properties, in the past two decades, major research efforts have …

The interferons (IFNs) are a family of cytokines that protect against disease by direct effects
on target cells and by activating immune responses. The production and actions of IFNs are …

▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

The STAT1 transcription factor is activated in response to many cytokines and growth
factors. To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in …

In the late 1960s, the essential role of T cells in antibody production was reported. This led to
our hypothesis that T-cell-derived soluble factors would have to be involved in the activation …

▪ Abstract During the last several years, the mechanism of IFNγ-dependent signal
transduction has been the focus of intense investigation. This research has recently …

▪ Abstract This essay summarizes my 40 years of research in immunology. As a young
physician, I encountered a patient with Waldenström's macroglobulinemia, and this inspired …

Janus kinases (Jaks) play an important role in signal transduction via cytokine and growth
factor receptors. A targeted inactivation of Jak2 was performed. Jak2−/− embryos are anemic …