Molecular bowls for inclusion complexation of toxic anticancer drug methotrexate

P Karmakar, TJ Finnegan, DC Rostam, S Taneja… - Chemical …, 2024 - pubs.rsc.org
We describe the preparation and study of novel cavitands, molecular bowls 16+ and 26+, as
good binders of the anticancer drug methotrexate (MTX). Molecular bowls are comprised of …

β-Cyclodextrin-bearing gold glyconanoparticles for the development of site specific drug delivery systems

A Aykaç, MC Martos-Maldonado, JM Casas-Solvas… - Langmuir, 2014 - ACS Publications
Three novel gold nanoparticles containing multiple long, flexible linkers decorated with
lactose, β-cyclodextrin, and both simultaneously have been prepared. The interaction of …

Controlling the Solubility, Release Rate and Permeation of Riluzole With Cyclodextrins

T Volkova, O Simonova, G Perlovich - Pharmaceutics, 2024 - mdpi.com
Riluzole (RLZ), a sodium channel-blocking benzothiazole anticonvulsant BCS class II drug,
is very slightly soluble in aqueous medium. To improve aqueous solubility and modulate …

[HTML][HTML] Addressing the complexities in measuring cyclodextrin-sterol binding constants: A multidimensional study

AM Anderson, I Manet, M Malanga, DM Clemens… - Carbohydrate …, 2024 - Elsevier
A class of cyclodextrin (CD) dimers has emerged as a potential new treatment for
atherosclerosis; they work by forming strong, soluble inclusion complexes with oxysterols …

Recent advances in drug delivery system for bioactive glycosides from traditional Chinese medicine

L Li, Y Feng, Y Hong, X Lin, L Shen - The American Journal of …, 2018 - World Scientific
Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the
prevention and treatment of various diseases. The materials that exert a therapeutic effect …

Dendritic Molecular Baskets for Selective Binding of Toxic Methotrexate

N Kumar, TJ Finnegan, S Taneja… - Angewandte Chemie …, 2024 - Wiley Online Library
We describe the preparation, assembly, recognition characteristics, and bioactivity of
dendritic basket 612−. This novel cavitand has a deep aromatic pocket with three (S) …

Selective binding of methotrexate to monomeric, dimeric and polymeric cyclodextrins

I Kritskiy, R Kumeev, T Volkova, D Shipilov… - New Journal of …, 2018 - pubs.rsc.org
The difference in the complexation affinity of methotrexate (MTX) to the naturally occurring α-
, β-and γ-cyclodextrins (CDs) as well as to the novel synthetic dimeric and polymeric β …

Comparative analysis of solubilization and complexation characteristics for new antifungal compound with cyclodextrins. Impact of cyclodextrins on distribution …

TV Volkova, GL Perlovich - European Journal of Pharmaceutical Sciences, 2020 - Elsevier
From a pharmaceutical standpoint, cyclodextrin-based products have deservedly gained
substantial market share due to their ability to improve undesirable physicochemical …

Use of hydroxypropyl β-cyclodextrin as a dual functional component in xanthan hydrogel for sustained drug release and antibacterial activity

B Zhang, J Wang, Z Li, M Ma, S Jia, X Li - Colloids and Surfaces A …, 2020 - Elsevier
A hydrogel of xanthan gum (XG) was improved by crosslinking hydroxypropyl β-cyclodextrin
(HPCD) physically to construct a novel drug delivery system. This hydrogel was full of the …

Biotin-functionalized targeting anti-tumor complex based on β-cyclodextrin and methotrexate

D Zhang, J Zhang, P Lv, Y Zhao, X Liao, C Gao… - Journal of Drug Delivery …, 2019 - Elsevier
The design and construction of tumor-targeted drug delivery systems provide us a facile
method to treat cancers selectively. In this work, a biotin-targeting inclusion complex based …