The ability of cancer cells to produce and to respond to their own growth factors (autocrine
secretion) has become a central concept linking oncogene and growth factor research …

Summary and Conclusions Growth factors, defined as polypeptides that stimulate cell
proliferation, are major growth-regulatory molecules for cells in culture and probably also for …

Drug sensitivity and resistance are conventionally quantified by IC50 or E max values, but
these metrics are highly sensitive to the number of divisions taking place over the course of …

Each of six peptides derived from the human epidermal growth factor (EGF) receptor very
closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian …

A related DNA fragment distinct from the epidermal growth factor receptor and ERBB2 genes
was detected by reduced stringency hybridization of v-erbB to normal genomic human DNA …

Type beta transforming growth factor (TGF-beta) is a two-chain polypeptide of 25,000
daltons isolated from many tissues, including bovine kidney, human placenta, and human …

The secretion of plasminogen activators has been implicated in the controlled extracellular
proteolysis that accompanies cell migration and tissue remodeling. We found that the human …

The hormone-dependent human breast cancer cell line MCF-7 secretes transforming growth
factor-8 (TGF-p), which can be detected in the culture medium in a biologically active form …

The complete amino acid sequence of rat transforming growth factor type 1 has been
determined. This growth factor, obtained from retrovirus-transformed fibroblasts, is …

We report that human breast cancer cells secrete a growth factor that is biologically and
immunologically similar to platelet-derived growth factor (PDGF). Serum-free medium …