Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production

YS Ko, JW Kim, JA Lee, T Han, GB Kim… - Chemical Society …, 2020 - pubs.rsc.org
Sustainable production of chemicals from renewable non-food biomass has become a
promising alternative to overcome environmental issues caused by our heavy dependence …

Expanding chemistry through in vitro and in vivo biocatalysis

EN Kissman, MB Sosa, DC Millar, EJ Koleski… - Nature, 2024 - nature.com
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Rewriting yeast central carbon metabolism for industrial isoprenoid production

AL Meadows, KM Hawkins, Y Tsegaye, E Antipov… - Nature, 2016 - nature.com
A bio-based economy has the potential to provide sustainable substitutes for petroleum-
based products and new chemical building blocks for advanced materials. We previously …

The metabolic origins of non-photorespiratory CO2 release during photosynthesis: a metabolic flux analysis

Y Xu, X Fu, TD Sharkey, Y Shachar-Hill… - Plant …, 2021 - academic.oup.com
Respiration in the light (RL) releases CO2 in photosynthesizing leaves and is a
phenomenon that occurs independently from photorespiration. Since RL lowers net carbon …

Adaptive laboratory evolution–principles and applications for biotechnology

M Dragosits, D Mattanovich - Microbial cell factories, 2013 - Springer
Adaptive laboratory evolution is a frequent method in biological studies to gain insights into
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …

The effects of alternate optimal solutions in constraint-based genome-scale metabolic models

R Mahadevan, CH Schilling - Metabolic engineering, 2003 - Elsevier
Genome-scale constraint-based models of several organisms have now been constructed
and are being used for model driven research. A key issue that may arise in the use of such …

Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization

AP Burgard, P Pharkya… - Biotechnology and …, 2003 - Wiley Online Library
The advent of genome‐scale models of metabolism has laid the foundation for the
development of computational procedures for suggesting genetic manipulations that lead to …

[LIBRO][B] The Control Handbook (three volume set)

WS Levine - 2018 - taylorfrancis.com
At publication, The Control Handbook immediately became the definitive resource that
engineers working with modern control systems required. Among its many accolades, that …

Pathway Tools version 19.0 update: software for pathway/genome informatics and systems biology

PD Karp, M Latendresse, SM Paley… - Briefings in …, 2016 - academic.oup.com
Pathway Tools is a bioinformatics software environment with a broad set of capabilities. The
software provides genome-informatics tools such as a genome browser, sequence …

Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network

J Förster, I Famili, P Fu, BØ Palsson… - Genome research, 2003 - genome.cshlp.org
The metabolic network in the yeast Saccharomyces cerevisiae was reconstructed using
currently available genomic, biochemical, and physiological information. The metabolic …