From the molecular level up to a blood vessel, thrombosis and hemostasis involves many
interconnected biochemical and biophysical processes over a wide range of length and time …

Computational models of various facets of hemostasis and thrombosis have increased
substantially in the last decade. These models have the potential to make predictions that …

While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …

Modeling thrombus growth in pathological flows allows evaluation of risk under patient-
specific pharmacological, hematological, and hemodynamical conditions. We have …

The formation of wall-adherent platelet aggregates is a critical process in arterial thrombosis.
A growing aggregate experiences frictional drag forces exerted on it by fluid moving over or …

Thrombosis under high-shear conditions is mediated by the mechanosensitive blood
glycoprotein von Willebrand factor (vWF). vWF unfolds in response to strong flow gradients …

Contraction of blood clots plays an important role in blood clotting, a natural process that
restores hemostasis and regulates thrombosis in the body. Upon injury, a chain of events …

The stability of a platelet thrombus under flow is believed to depend strongly on the local
hemodynamics and on the thrombus' porosity, permeability, and elasticity. A two-phase …

Gastric mucus is a polyelectrolyte gel that serves as the primary defense of the stomach
lining against acid and digestive enzymes. Mucus is released from granules in specialized …

Subclinical leaflet thrombosis (SLT) is a potentially serious complication of aortic valve
replacement with a bioprosthetic valve in which blood clots form on the replacement valve …