The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …

Background Mitochondrial dysfunction has been linked to the development of inflammatory
bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. We employed …

Purpose Previous studies have suggested a potential association between gut microbiota
and neurological and psychiatric disorders. However, the causal relationship between gut …

Background We aimed to investigate the protein pathways linking obesity and lifestyle
factors to coronary artery disease (CAD). Methods Summary-level genome-wide association …

The rise of new media has greatly changed the lifestyles, leading to increased time on these
platforms and less time spent reading. This shift has particularly profound impacts on early …

The prior observational research on the impact of polyunsaturated fatty acid (PUFA)
supplementation on osteoarthritis (OA) patients had yielded inclusive outcomes. This study …

Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators
of this relationship are not fully understood. Given that obesity strongly influences circulating …

Motivation Colocalization analysis is commonly used to assess whether two or more traits
share the same genetic signals identified in genome-wide association studies (GWAS), and …

Alternative splicing generates functional diversity in isoforms, impacting immune response to
infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and …