Toxicological data bank bridges the gap between environmental risk assessment and green organic chemical design in One Health world

XX Shi, ZZ Wang, XL Sun, YL Wang, HX Liu… - Green …, 2023 - pubs.rsc.org
In the conceptual frame of “One Health”, the safety crisis caused by various toxicological
issues due to chemical exposure is of great concern. The urgent demand for …

The molecular determinants of pesticide sensitivity in bee pollinators

C Bass, A Hayward, BJ Troczka, J Haas… - Science of the Total …, 2024 - Elsevier
Bees carry out vital ecosystem services by pollinating both wild and economically important
crop plants. However, while performing this function, bee pollinators may encounter …

A Locomotor Deficit Induced by Sublethal Doses of Pyrethroid and Neonicotinoid Insecticides in the Honeybee Apis mellifera

M Charreton, A Decourtye, M Henry, G Rodet… - PloS one, 2015 - journals.plos.org
The toxicity of pesticides used in agriculture towards non-targeted organisms and especially
pollinators has recently drawn the attention from a broad scientific community. Increased …

Conservation of the voltage‐sensitive sodium channel protein within the Insecta

JJ Silva, JG Scott - Insect molecular biology, 2020 - Wiley Online Library
The voltage‐sensitive sodium channel (VSSC) is essential for the generation and
propagation of action potentials. VSSC kinetics can be modified by producing different splice …

Eukaryotic voltage-gated sodium channels: on their origins, asymmetries, losses, diversification and adaptations

JE Fux, A Mehta, J Moffat, JD Spafford - Frontiers in Physiology, 2018 - frontiersin.org
The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was
a limiting factor in the evolution of nervous systems. Two rounds of domain duplications …

Molecular basis of selective resistance of the bumblebee BiNav1 sodium channel to tau-fluvalinate

S Wu, Y Nomura, Y Du, BS Zhorov… - Proceedings of the …, 2017 - National Acad Sciences
Insecticides are widely used to control pests in agriculture and insect vectors that transmit
human diseases. However, these chemicals can have a negative effect on nontarget …

Honey bees long-lasting locomotor deficits after exposure to the diamide chlorantraniliprole are accompanied by brain and muscular calcium channels alterations

A Kadala, M Charreton, P Charnet, C Collet - Scientific Reports, 2019 - nature.com
Diamides belong to one of the newest insecticides class. We characterized cellular effects of
the first commercialized diamide, chlorantraniliprole (ChlorAnt). ChlorAnt not only induces a …

Pyrethroids in an AlphaFold2 model of the insect sodium channel

BS Zhorov, K Dong - Insects, 2022 - mdpi.com
Simple Summary Pyrethroids are a major class of insecticides for controlling arthropod pests
and human disease transmitting vectors. Resistance to pyrethroid insecticides presents a …

[HTML][HTML] Unravelling impacts of the insecticide deltamethrin on neuronal sodium channels in honey bees: Molecular insights and behavioural outcomes

A Kadala, M Kaabeche, M Charreton, J Mutterer… - Chemosphere, 2024 - Elsevier
The current risk assessment framework for insecticides suffers from certain shortcomings in
adequately addressing the effects of low doses on off-target species. To remedy this gap, a …

Cardiotoxicity of the diamide insecticide chlorantraniliprole in the intact heart and in isolated cardiomyocytes from the honey bee

M Kaabeche, M Charreton, A Kadala, J Mutterer… - Scientific Reports, 2024 - nature.com
In honey bees, circulation of blood (hemolymph) is driven by the peristaltic contraction of the
heart vessel located in the dorsal part of the abdomen. Chlorantraniliprole (CHL) is an …