By focusing on essential features, while averaging over less important details, coarse-
grained (CG) models provide significant computational and conceptual advantages with …

Biomolecular systems possess unique, structure-encoded dynamic properties that underlie
their biological functions. Recent studies indicate that these dynamic properties are …

Exploring recent developments in the field, Coarse-Graining of Condensed Phase and
Biomolecular Systems examines systematic ways of constructing coarse-grained …

Biomolecules adopt a dynamic ensemble of conformations, each with the potential to
interact with binding partners or perform the chemical reactions required for a multitude of …

Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage
sensors and one pore domain. Because of high-level structural flexibility, the first …

Structural studies of large proteins and protein assemblies are a difficult and pressing
challenge in molecular biology. Experiments often yield only low-resolution or sparse data …

Normal mode analysis (NMA) is a technique that can be used to describe the flexible states
accessible to a protein about an equilibrium position. These states have been shown …

X-ray scattering is uniquely suited to the study of disordered systems and thus has the
potential to provide insight into dynamic processes where diffraction methods fail. In …

While the energy landscape theory of protein folding is now a widely accepted view for
understanding how relatively weak molecular interactions lead to rapid and cooperative …

The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II
but requires a reduced subset of general transcription factors for promoter-dependent …